Joint & Disc, Premier

Technical Bulletin Premier Joint & Disc is a premier nature-based botanical formula, clinically formulated to support a healthy inflammatory response and minor pain relief from normal day to day joint wear and tear,* specific to: Joint mobility* Disc health* Healthy cartilage* Sports recovery / muscle function* Premier Joint & Disc is scientifically formulated to deliver an aggressive panel of clinically reviewed ingredients which contain powerful phytochemical compounds designed to directly promote a healthy inflammatory response by targeting key chemical signaling pathways that have the capacity to modulate pro-inflammatory cytokines and proteins associated with minor pain from everyday activities.*    Triple Strength Formula This triple strength formula is tailored with three clinically reviewed ingredients designed to provide long-term support of the joints, discs and musculoskeletal systems of the body.*  Leading the list of this trifecta is the distinguished, centuries-old Andrographis paniculata, patented as ParActin™. This revered botanical continues to be regarded by health professionals worldwide as one of nature’s superstars providing reliable results to their clients who need immediate joint support.*  Complementing this notable ingredient is the well-researched White Willow (bark) Extract, which provides the highly effective compound, salicin.  Lastly, anchoring the trio, is Sodium Hyaluronate which is well known for its active constituent, hyaluronic acid. Premier Joint & Disc is a comprehensive formula offering an elegant lineup of advanced, full spectrum botanical compounds that promote healthy joints, discs and connective tissue function.*   Andrographis Paniculata What is it? Andrographis paniculata, an annual herbaceous plant in the family Acanthaceae, is one of the most commonly used medicinal plants in the traditional systems of Traditional Chinese and Ayurvedic medicine.* It continues to be widely cultivated in India, China, and Southeastern Asia.  Known as the “King of Bitters,” its bioactive components called andrographolides have been extensively tested and have demonstrated their ability to promote modulatory activity at multiple points in the chemical signaling pathway of the inflammatory response systems of the body.* How Does it work? PRL selected ParActin™, a nature-sourced, patented extract of Andrographis paniculata, as a primary ingredient in our formulation, Premier Joint & Disc.  ParActin™ is the result of over 20 years of research and development including more than 30 studies of in vitro / in vivo animal models and human clinical trials.  This extract’s diterpenoid profile is standardized to clinically established levels that promote a healthy inflammatory response due to the targeting of key chemical signaling pathways which support healthy NF-kB levels and activity, known as the master regulator of our inflammatory response systems.*   Salicin What is it? Salicin is a natural compound derived from the bark of the White Willow Tree. The use of White Willow Bark dates back to the early origins of medicine when Hippocrates first documented its efficacy in supporting the body during episodes of minor aches and pains. How does it work? Recent science has found evidence that White Willow Bark’s primary phytochemical, Salicin, demonstrates a beneficial effect on both arachidonic acid-derived eicosanoids and cytokine compounds.* Randomized human trials have illustrated Salicin’s ability to influence the inflammatory response systems as a natural inhibitor of both the cyclooxygenase-2 (COX-2) and 5-lipoxygenase enzymes, beneficially modulating the activity of the protein complex nuclear factor-kappa B (NF-kB), thereby regulating inflammatory cytokine production.*   Hyaluronic Acid What is it? Optimal levels of synovial fluid in joint cavities is essential to maintaining healthy joints and mobility. Synovial fluid is the “viscous fluid” that supports the integrity of joints by shuttling in nutrients and keeping the cartilage hydrated and healthy.  Synovial fluid contains high levels of hyaluronic acid (HA) in its membrane to promote its fluid viscosity and is critical to preserving the normal cartilaginous matrix.* HA is a naturally occurring polymer found in all joints, discs, connective tissue, tendons, bones and cartilage (especially the hyaline cartilage, which covers the ends of bones to provide cushioning).*  How does it work? HA is considered to be a glycosaminoglycan, composed of alternating units of n-acetyl-d-glucosamine and d-glucuronate.  This structure enables it to have the capacity to attract and retain large volumes of water in the extracellular matrix of tissues, various layers of the skin, and within the synovial fluid.  Ensuring optimal levels of hyaluronic acid is thus crucial to healthy joint function.* In Premier Joint & Disc, we use a stabilized form of hyaluronic acid called sodium hyaluronate which is more stable and less prone to oxidation. It is clearly the preferred form to support the health of joints and cartilage.*   Top Ten Premier Joint Support Products 1. Premier Joint & Disc Nature-sourced botanical formula, clinically formulated to support a healthy inflammatory response and minor pain relief specific to: ● Joint mobility ● Disc health ● Healthy cartilage ● Sports recovery / muscle function.* 2. Inflammacidin With 15 million PU of total protease activity, this formula is clinically designed to target a healthy inflammatory response without unwanted side effects.* Research demonstrates that high proteolytic activity acts as an essential modulator in supporting healthy inflammatory response, specific to the breakdown of proteins. Thus, high proteolytic activity may promote healthy platelet function and also support joint comfort. 3. EPA / DHA Marine Liquid Research studies have shown that omega-3 fatty acids are able to: 1) antagonize arachidonic acid-induced eicosanoid formation; 2) help generate resolvins and protectins to aid the body’s “cleanup” response to the arachidonic acid cascade; and 3) promote neurological health, cytokine balance and joint health.* 4. Tranquinol This formula supports overall body relaxation and mental tranquility by promoting a healthy neuromodulation response during times of stress. It helps counteract stress via the hypothalamus-pituitary-adrenal axis.* 5. Premier Glucosamine Sulfate This formula provides the premier form of glucosamine as glucosamine sulfate (shellfish-free), which promotes targeted joint, ligament and connective tissue support.* 6. Premier Vitamin D3+K2 At a 5,000 IU of D3 and 180 mcg. of K2 per capsule, this product contains an exclusive 100% vegan/ vegetarian friendly formula with both vitamin D3 and K2 present in clinically established dosages that promote bone health as well as cardiovascular health.* 7. Asta Complete-FX This formula features algae-sourced astaxanthin which has the significant ability to quench ROS (reactive oxygen species) and free radicals (including the superoxide anion, hydrogen peroxide, singlet oxygen, etc.) in both the inner and outer layers of the cellular membrane -- unlike most other antioxidants which act on the inner membrane only (such as  vitamin E) or the outer membrane only (such as vitamin C).* 8. PQQ Complex This formula offers PQQ (pyrroloquinoline quinone), a unique B vitamin-like nutrient, which helps neutralize free radical stress and helps modulate neurotransmitter activity.  It promotes the overall health of mitochondrial DNA and may help support healthy levels of nerve growth factor and supporting the functions of synaptic and intracellular neuronal responses. 9. Premier Turmeric This product contains high quality, organic turmeric with a high concentration of active compounds known as curcuminoids, present as a naturally occurring component of turmeric. They possess significant antioxidant capabilities.* 10. Premier Complete B Capsules This product offers all 8 types of critical B vitamins that are all present in their fully activated, blood-circulating forms, including vitamin B6, which has been shown to directly support tendon health and nerve comfort.